Los Panteros are the “street-hard natives of Santo Ileso,” according to associate art director Stephen Quirk. Each gang has its home turf regions and specific gameplay styles. Santo Ileso is also home to the Saints three rivals in the new game: Los Panteros, Marshall Defense Industries, and The Idols. Beyond more developed, urban settings, Santo Ileso also has a ton of open desert and natural landmarks to explore. These range from the glitzy and glamorous El Dorado district to the grime and grit of Rancho Providencia. Santo Ileso is a massive sandbox based on the American southwest with nine distinct regions.